Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water to give the aquo complex cis-[PtCl(NH3)2(H2O)] , in a process termed aquation. Dissociation of the chloride is favored inside the cell because the intracellular chloride concentration is only 3–20% of the approxi… WebCisplatin (DDP) has been a significant tumor chemotherapy against various solid malignant tumors, including lung adenocarcinoma, since it was approved by the Food and Drug Association in 1978.7Platinum chemotherapy drugs, represented by DDP, are antitumor agents.
A review on the effects of current chemotherapy drugs and …
WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … WebOct 5, 2014 · Cisplatin in cancer therapy: molecular mechanisms of action Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic … cyproterone acetate ethinyl estradiol
Pharmaceutics Free Full-Text Pd (II) and Pt (II) Trinuclear ...
WebNov 24, 2024 · 1.1. Lung Cancer. Among all forms of cancer, lung cancer is the leading cause of mortality worldwide [1, 2]. Despite advances in development of new treatment modalities, the overall 5-year survival rate has only slightly increased over 2.5 decades, remaining at approximately 16% [4, 5].Early diagnostic procedures and hits, and effective … WebNov 2, 2024 · Among other cancers, cisplatin is used as a first-line treatment for: leukemia lymphoma breast cancer testicular cancer ovarian cancer head and neck cancer cervical … WebJul 19, 2024 · The mechanisms of anti-cancer drugs brings together learning about transition metals, DNA and ethical considerations in science and medicine. This is an opportunity for cross-curricular debate within … cyproterone 100mg tablets pil