Cisplatin myopathy
WebApr 7, 2024 · Mitochondrial dysfunction affects cells with high energy needs such as neural, skeletal muscle, heart, and liver cells and plays a crucial role in type 2 diabetes, as well as Parkinson’s, Alzheimer’s diseases, ischemia, stroke, cancer, and age-related disorders.
Cisplatin myopathy
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WebOur patients received cisplatin before carboplatin and all developed a mild sensory neuropathy while taking cisplatin (one had Lhermitte’s sign). This neuropathy appeared … WebJan 1, 2024 · After entering the hair cells, cisplatin causes hair cell death via DNA damage, redox system imbalance, and mitochondrial and endoplasmic reticulum dysfunction, culminating in programmed cell death including apoptosis, necroptosis, autophagic death, pyroptosis, and ferroptosis.
WebFeb 1, 2024 · Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or testicles. Cisplatin is an antineoplastic agent (cancer medicine). It interferes with the growth of cancer cells, which are eventually destroyed by the body. This medicine is to be given only by or under the direct supervision of a doctor. WebDec 21, 2024 · On this basis, mitochondrial myopathies are a heterogeneous group of diseases mainly originating by the inability of mitochondria to sustain cellular energy demands due to structural and functional alterations of the …
WebThis exposure to cisplatin results in a range of toxicities . In addition, circulating …. Prevention of chemotherapy-induced nausea and vomiting in adults. …remains necessary, at least in patients receiving cisplatin -based chemotherapy. This was illustrated by a randomized trial in which patients receiving cisplatin chemotherapy were ... WebSep 14, 2024 · The main symptom of a myopathy is muscle weakness, more often in the legs and arms than in the hands or feet. This type of disorder may also affect the respiratory muscles, which can lead to ...
WebForty-five patients with cisplatin-induced peripheral neuropathy (PN) were evaluated retrospectively after treatment with cumulative doses of cisplatin ranging from 201 to …
WebSep 18, 2024 · Cisplatin is a first-line therapy that is widely used to treat several types of cancer, including Ewing sarcoma, rhabdomyosarcoma and osteosarcoma. However, … birdtown ncWebAll myopathy is characterized by muscle weakness, most commonly in the upper arms, shoulders, and thighs. Other general symptoms you may have with myopathy include: … birdtown clevelandWebDec 13, 2024 · The neurologic complications of platinum compounds (cisplatin, carboplatin, and oxaliplatin) and of biologic response modifiers and molecularly targeted agents (both orally administered and therapeutic monoclonal antibodies) are discussed elsewhere, as are strategies to prevent and manage CIPN. bird town north carolinaWebMay 19, 2024 · Cisplatin treatment may cause hyponatremia through SIADH, related to both higher secretion of and sensitivity to ADH ( 32 ). Nausea and vomiting, which are common side effects of platinum-derived chemotherapy, are … dance moms season 8 episode 14 awardsWebMar 1, 2012 · In this paper, we examine the nature of ROS-induced damage on key cellular targets of oxidative stress. We also review evidence … bird tour costa ricaWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be … dance moms season 8 episode 8 a team on trialWebCisplatin is a type of chemotherapy. It destroys quickly dividing cells, such as cancer cells. Find out more about how chemotherapy works How do you have cisplatin? You have cisplatin as a drip into your bloodstream (intravenously). Into your bloodstream You might have treatment through a long plastic tube that goes into a large vein in your chest. birdtown community center cherokee nc