WebMar 19, 2024 · CTCF and BORIS cooperate with additional Testis-specific transcriptional regulators to regulate gene expression in developing male gametes. CCCTC-binding … WebMay 6, 2013 · CTCF has it all. The transcription factor binds to tens of thousands of genomic sites, some tissue-specific, others ultra-conserved. It can act as a transcriptional activator, repressor and insulator, and it can pause transcription. CTCF binds at chromatin domain boundaries, at enhancers and gene promoters, and inside gene bodies.
CTCFBSDB 2.0: A database for CTCF binding sites and genome
WebNov 13, 2024 · In contrast, overexpression of Hottip lncRNA (Hottip-Tg) in the mice bone marrow hematopoietic compartment perturbs hematopoietic stem cell (HSC) self-renewal and differentiation leading to AML like disease by reinforcing CTCF defined TADs, enhancing chromatin accessibility within TADs, and upregulating gene transcription in … WebFeb 17, 2024 · In this article, Luo et al. discovered that HOTTIP lncRNA and CTCF/cohesin co-occupied a subset of the AML genome driven by HOTTIP aberration. HOTTIP regulates the CTCF boundary and TAD topology of β-catenin and its target loci by binding to complementary sequences to form R-loop structures that drive leukemic transcription … sp2-0027 input is too long 2499 characters
Comparison of CTCF binding sites in hematopoietic stem and …
WebMay 3, 2024 · In order to image CTCF and cohesin without altering their endogenous expression levels, we used CRISPR/Cas9-mediated genome editing to homozygously tag Ctcf and Rad21 with HaloTag in mouse … WebAcronym. Definition. TSCF. The Social Capital Foundation (Brussels, Belgium) TSCF. Tertiary Students Christian Fellowship (New Zealand) TSCF. Total Scatter Factor. TSCF. WebJul 13, 2024 · CTCF binding sites in MKs have been added for comparison (dark green, present). Categories: (I) Open chromatin regions present in all five cell types. ... MK, HSC, CMP and MEP ATAC-seq reads ... teams add in nicht in outlook