Cytosolic dna-sensing pathway是什么

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August undefined, 2024

WebKEGG PATHWAY: Cytosolic DNA-sensing pathway WebCytosolic DNA-sensing pathway (WP4655) Homo sapiens. ... New DNA-sensing pathway feeds RIG-I with RNA. Cao X. Nat Immunol. 2009 Oct;10(10):1049–51. …

Critical role of cytosolic DNA and its sensing adaptor STING in …

WebCytosolic DNA-mediated production of type I IFNs (mainly IFN-β) requires the transcription factor IFN ... 2012. Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing … ctscope

Cytosolic DNA sensing by cGAS: regulation, function, and human …

WebThe second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these … Web1 language. The cGAS–STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to senescence [1] or to the activation of defense mechanisms. DNA is normally found in the nucleus of the cell. WebNov 30, 2024 · Cytosolic DNA sensing is a fundamental mechanism by which organisms handle various stresses, including infection and genotoxicity. The hematopoietic system is sensitive to stresses, and hematopoietic changes are often rapid and the first response to stresses. Based on the transcriptome database, cytosolic DNA sensing pathways are … earth地球电脑版官网

Cytosolic DNA-sensing pathway Pathway - PubChem

WebUpon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell. WebDec 20, 2012 · To determine whether cGAS is important in the DNA sensing pathway in human cells, we established a THP1 cell line stably expressing a shRNA targeting h-cGAS (fig. S4D). The knockdown of h-cGAS strongly inhibited IFN-β induction by HT-DNA transfection or infection by vaccinia virus, another DNA virus, but not by Sendai virus (fig. … ear tibcoWebCytosolic DNA sensing is emerging to be a critical component of the antitumor immune response by jumpstarting innate immune responses subsequent to the stimulation of the cGAS and STING pathway. Investigating the accumulation of DNA species in the cytosol is therefore an essential readout for promising anticancer strategies. ct s/contrast

"WebMay 5, 2013 · Cytosolic signaling pathways activated by DNA have been uncovered, new DNA receptors proposed, and we now know that innate DNA recognition is closely … " - Cytosolic dna-sensing pathway是什么

Cytosolic dna-sensing pathway是什么

Critical role of cytosolic DNA and its sensing adaptor STING in …

WebApr 30, 2024 · DNA is a pathogen-associated molecular pattern when delivered to the host cytoplasm by viral or microbial infection, and a danger-associated molecular pattern … WebJan 1, 2024 · Importantly, we found that the pharmacologic inhibition of STING activation can reduce AAD development in mice. Our study findings suggest that the cytosolic DNA–mediated activation of cytosolic DNA sensing adaptor STING plays a critical role in aortic degeneration and is a potential therapeutic target for treating sporadic AAD.

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WebApr 13, 2024 · The authors next sought to explore the impact of compromising this DNA sensing pathway by eliminating the intermediate kinase ZAK. T cell-specific deletion of Zak did not affect T cell development or maturation. Nuclear DNA damage and cytosolic DNA accumulation also occurred normally when Zak-deficient CD4 + T cells age. Upstream … WebFeb 10, 2024 · Isolation of endogenous cytosolic DNA from cultured cells. Shayla R. Mosley 1,3,* and Kristi Baker 1,2,4,** 1 Department of Oncology, University ... Isolated cyDNA can also be used to stimulate other cells to determine either the sensitivity of their cyDNA-sensing pathways, such as that of STING, or the stimulatory capacity of cyDNA …

WebFeb 1, 2024 · The cGAS–STING Pathway Links Nucleic Acid Sensing to Immune Response. It has been long known that DNA can trigger immune responses, even before DNA was recognized as the genetic blueprint [1].The response to pathogenic DNA is the basis for the evolution of restriction modification systems in bacteria, where restriction … WebMany studies have demonstrated the involvement of DNA-sensing pathways in antitumor responses as well as tumor development. Cancer cells often contain cytosolic DNA, which may not be present under physiological conditions. ... Jiang N, May H II, Li T, et al. Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs …

WebApr 30, 2024 · The cGAS–STING signaling pathway senses cytosolic DNA derived from either viral/bacterial infection or self-DNA. DNA is a pathogen-associated molecular pattern when delivered to the host cytoplasm by viral or microbial infection, and a danger-associated molecular pattern when leaked into the cytoplasm from damaged mitochondria or … WebDec 30, 2024 · Cytosolic DNA and abnormal activation of cytosolic DNA sensing signaling play critical roles in sporadic aortic destruction, dilatation, dissection, and rupture. Targeting cytosolic DNA sensing adaptor …

WebSep 10, 2024 · Cytosolic DNA Sensing in Organismal Tumor Control. Besides constituting a first layer of defense against microbial challenges, the detection of cytosolic DNA is …

WebDec 30, 2024 · Recent evidence has indicated that cytosolic DNA and abnormal activation of the cytosolic DNA sensing adaptor STING (stimulator of interferon genes) play a critical role in vascular … ctscopsWebMay 23, 2013 · LRRFIP1 senses cytosolic DNA and phosphorylates β-catenin, which translocates to the nucleus and promotes IFN-β transcription. The DNA-PKc-Ku70-Ku80 … cts control systemsWebActivation of cytosolic DNA sensing pathways impacts on autophagy and tumor antigens (Ags) cross-presentation in DCs. Type-I IFNs production by DCs actually represents the … earth意味英語WebNov 30, 2024 · Based on the transcriptome database, cytosolic DNA sensing pathways are widely expressed in the hematopoietic system, and components of these pathways may be expressed at even higher levels in hematopoietic stem and progenitor cells (HSPCs) than in their certain progeny immune cells. Recent studies have described a previously … ctscorp.comWebBiological pathway information for Cytosolic DNA-sensing pathway from WikiPathways. cts copisteria campobassoWebDec 20, 2012 · Our results not only demonstrate that cGAS is a cytosolic DNA sensor that triggers the type I interferon pathway, but also reveal a mechanism of immune signaling … earth意味WebMay 23, 2013 · Although there is also a suggestion that DNA sensing might additionally occur in the nucleus (Kerur et al., 2011; Li et al., 2012), efforts have focused on identifying the pathways that mediate the sensing of DNA in the cell cytosol and link it to inflammation (Figure 4). Download : Download high-res image (595KB) earth意味は