Hif bnip3
Web6 de out. de 2024 · HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. Web2 de set. de 2024 · 3.3. HIF-1α/BNIP3 Pathway Was Activated during Luteolysis. Previous studies have revealed that hypoxia is involved in the apoptosis of luteal cells in vitro [], implying that HIF-1α may participate in apoptosis during luteal regression in vivo.Thus, we detected the expression changes of HIF-1α signaling and then found an obvious …
Hif bnip3
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WebOverexpression of BNIP3 in Rat-1 fibroblasts and breast cancer cells (MCF7) induces apoptosis by binding to and inhibiting the antiapoptotic proteins Bcl-2 and Bcl-xL. 57 Hypoxia induced apoptosis mediated by … WebBNIP3 is an atypical BH3-only protein that is known to cause mitochondrial dysfunction and cell death, but in parallel has also a role in protecting against cell death by inducing mitophagy. The mechanism for this process, however, remains poorly understood.
Web18 de jan. de 2024 · In the neonatal corpus luteum, HIF-1α up-regulated BNIP3 expressions, which contributed to the autophagic initiation by disrupting beclin1 from Bcl-2/beclin1 … http://www.aquaticjournal.com/article/doi/10.7541/2024.2024.261
WebIn contrast, adenovirus-mediated BNIP3 overexpression significantly reversed the decreased mitophagy, and prevented enhanced kidney damage in tubular HIF-1α … Web18 de mar. de 2024 · HIF-1a was stabilised by 4 and 6 h OGD in PC12 cells and 2 h OGD onwards in primary neurons. A panel of hypoxic genes were upregulated by the OGD treatments depending on the duration. ... Bnip3 levels in PC12 cells were not changed during the shorter period of OGD (from 2 to 12 h), ...
Web27 de dez. de 2024 · HIF-1 α exerts its antiapoptotic function through transcriptional activation of antiapoptotic proteins: Bcl-2, apoptosis inhibitor (IAP-2), and GLUT1. On the other hand, a functional pathway of HIF-1 α can activate proapoptotic proteins: p53, Bax, and BNIP3 [ 5 ].
Web目前认为低氧是通过hif－1诱导的非典型性唯bh3域蛋白 bcl－2/e1b 19 kda交互蛋白 3[bnip3/bnip3l(nix)]和mtor而介导细胞发生自吞噬作用的。 这些线粒体相关BNIP蛋白能介导线粒体自吞噬(mitophagy)，而线粒体自吞噬反应能控制活性氧族(reactive oxygen species，ROS)的产生和DNA受损的代谢，从而使细胞产生适应性存活 ... camping les fontaines tohapiWebNational Center for Biotechnology Information camping les genetsWebAB - Mesquita et al. show that genetic deficiency of HIF-1α in the myeloid compartment promotes de novo lipogenesis through the BNIP3/mTOR/SREBP-1c axis. This is associated with higher susceptibility to Leishmania donovani infection, which is reduced upon pharmacological inhibition of fatty acid synthesis. KW - acetate KW - FASN KW - HIF-1α firth homes sheffieldWebAB - Mesquita et al. show that genetic deficiency of HIF-1α in the myeloid compartment promotes de novo lipogenesis through the BNIP3/mTOR/SREBP-1c axis. This is … firth homesWeb摘要：目的 探讨乙酸钠(NaAc)对氧糖剥夺(OGD)损伤后皮质神经元的作用及低氧诱导因子-1α(HIF-1α)表达的影响。方法 将OGD处理的皮质神经元作为脑缺血模型，采用细胞存活实验(CCK-8)、乳酸脱氢酶(LDH)释放实验检测NaAc处理后的神经元存活情况，Western blot方法检测OGD损伤后、NaAc处理后神经元中HIF-1α蛋白 ... camping les genêts penmarchWeb7 de ago. de 2024 · HIF-1α-BNIP3 signaling pathway contributes to mitophagosome formation in renal tubular cells in confocal assay. Representative immunofluorescence images (A) and summarized data (C) showing the inhibitory effect of HIF-1α siRNA on H/R-induced mitophagosome formation as indicated by the colocalization of LC3B with … camping les fougeres rivedouxWeb27 de jul. de 2024 · (Bnip3) was substantially upregulated in the inner retinal layer after retinal I/R. In this regard, we further examined Bnip3 depletion in retinal neurons in vitro … camping les genêts camping aveyron